Development of Organ Preservation Solutions

Chen F, Nakamura T, Wada H. Development of new organ preservation solutions in kyoto university. Yonsei Med J 2004;45(6):1107-14.

Chen F, Fukuse T, Hasegawa S, Bando T, Hanaoka N, Kawashima M, Sakai H, Hamakawa H, Fujinaga T, Nakamura T, Wada H. Effective application of ET-Kyoto solution for clinical lung transplantation. Transplant Proc 2004;36(9):2812-5.

Omasa M, Hasegawa S, Bando T, Hanaoka N, Yoshimura T, Nakamura T, Wada H. Application of ET-Kyoto solution in clinical lung transplantation. Ann Thorac Surg 2004;77(1):338-9.

Wada H, Omasa M, Nakamura T. Development of new organ preservation solutions and their application. Recent Res Devel Resp Critical Care Med 2002;2:181-193.

Yoshida H, Okuno H, Kamoto T, Habuchi T, Toda Y, Hasegawa S, Nakamura T, Wada H, Ogawa O, Yamamoto S. Comparison of the effectiveness of ET-Kyoto with Euro-Collins and University of Wisconsin solutions in cold renal storage. Transplantation 2002;74(9):1231-6.

Fukuse T, Hirata T, Omasa M, Wada H. Effect of adenosine triphosphate-sensitive potassium channel openers on lung preservation. Am J Respir Crit Care Med 2002;165(11):1511-5.

Hirata T, Fukuse T, Ishikawa S, Miyahara R, Wada H. Addition of ATP and MgCl2 to the preservation solution attenuates lung reperfusion injury following cold ischemia. Respiration 2001;68(3):292-8.

Bando T, Albes JM, Schone J, Wada H, Hitomi S, Wahlers T, Schaefers HJ. Significance of cyclic adenosine monophosphate and nitroglycerin in ET-Kyoto solution for lung preservation. Ann Thorac Surg 2000;69(3):887-91; discussion 891-2.

Kawashima M, Bando T, Nakamura T, Isowa N, Liu M, Toyokuni S, Hitomi S, Wada H. Cytoprotective effects of nitroglycerin in ischemia-reperfusion-induced lung injury. Am J Respir Crit Care Med 2000;161(3 Pt 1):935-43.

Ueda M, Hasegawa S, Nakamura T, Hirata T, Fukuse T, Suzuki Y, Wada H. Effects of dibutyryl cyclic adenosine monophosphate on the ultrastructure of endothelial cells in rat lungs cold preserved for 15 hours. Eur Surg Res 2000;32(5):289-96.

Fukuse T, Hirata T, Nakamura T, Ueda M, Kawashima M, Hitomi S, Wada H. Role of saccharides on lung preservation. Transplantation 1999;68(1):110-7.

Ueda M, Kosaka S, Hirata T, Fukuse T, Suzuki Y, Hitomi S, Wada H. Mitochondrial injuries in rat lungs preserved for 17 h: An ultrastructural study. Eur Surg Res 1999;31(2):162-72.

Wu SF, Suzuki Y, Kitahara AK, Wada H, Nishimura Y. Skin flap storage with intracellular and extracellular solutions containing trehalose. Ann Plast Surg 1999;43(3):289-94.

Bando T, Albes JM, Nusse T, Wada H, Hitomi S, Wahlers T, Schaefers H. Comparison of euro-collins solution, low-potassium dextran solution containing glucose, and ET-kyoto solution for lung preservation in an extracorporeal rat lung perfusion model. Eur Surg Res 1998;30(5):297-304.

Kitahara AK, Suzuki Y, Zhan CW, Wada H, Nishimura Y. Evaluation of new improved solution containing trehalose in free skin flap storage. Br J Plast Surg 1998;51(2):118-21.

Nakamura T, Hirata T, Fukuse T, Ueda M, Hitomi S, Wada H. Dibutyryl cyclic adenosine monophosphate attenuates lung injury caused by cold preservation and ischemia-reperfusion. J Thorac Cardiovasc Surg 1997;114(4):635-42.

Zhan CW, Suzuki Y, Kitahara AK, Wada H, Nishimura Y. Prolongation of ischaemic tolerance of rat skeletal muscle by trehalose. Scand J Plast Reconstr Surg Hand Surg 1997;31(3):197-201.

Fukuse T, Hirata T, Ueda M, Hitomi S, Wada H. Effects of Euro-Collins, University of Wisconsin, and new extracellular-type trehalase-containing Kyoto solutions in an ex vivo rat lung preservation model. Transplantation 1996;62(9):1212-7.

Isowa N, Hitomi S, Wada H. Trehalose-containing solutions enhance preservation of cultured endothelial cells. Ann Thorac Surg 1996;61(2):542-5.

Kitahara AK, Suzuki Y, Zhan CW, Wada H, Nishimura Y. Preservation of skin free-flap using trehalose. J Surg Res 1996;62(1):130-4.

Kosaka S, Bando T, Liu C, Suzuki Y, Hitomi S, Wada H. Ultrastructural changes in canine lung preserved in newly developed solutions. J Surg Res 1996;63(2):467-73.

Liu CJ, Ueda M, Kosaka S, Hirata T, Yokomise H, Inui K, Hitomi S, Wada H. A newly developed solution enhances thirty-hour preservation in a canine lung transplantation model. J Thorac Cardiovasc Surg 1996;112(3):569-76.

Wada H, Fukuse T, Nakamura T, Liu CJ, Bando T, Kosaka S, Ariyasu T, Hitomi S. ET-Kyoto solution for 48-hour canine lung preservation. Ann Thorac Surg 1996;61(3):963-8.

Wada H, Liu CJ, Hirata T, Bando T, Kosaka S. Effective 30-hour preservation of canine lungs with modified ET-Kyoto solution. Ann Thorac Surg 1996;61(4):1099-105.

Zhan CW, Suzuki Y, Kitahara AK, Wada H, Nishimura Y. Preservative effects of trehalose on rat muscle flaps. Ann Plast Surg 1996;37(5):538-44.

Liu CJ, Bando T, Hirai T, Hirata T, Yagi K, Yokomise H, Inui K, Hitomi S, Wada H. Improved 20-hour canine lung preservation with a new solution--ET-Kyoto solution. Eur J Cardiothorac Surg 1995;9(10):548-52.

Bando T, Kosaka S, Liu C, Hirai T, Hirata T, Yokomise H, Yagi K, Inui K, Hitomi S, Wada H. Effects of newly developed solutions containing trehalose on twenty-hour canine lung preservation. J Thorac Cardiovasc Surg 1994;108(1):92-8.

Hirata T, Fukuse T, Liu CJ, Muro K, Yokomise H, Yagi K, Inui K, Hitomi S, Wada H. Effects of trehalose in canine lung preservation. Surgery 1994;115(1):102-7.

Hirata T, Yokomise H, Fukuse T, Muro K, Inui K, Yagi K, Hitomi S, Wada H. Effects of trehalose in preservation of canine lung for transplants. Thorac Cardiovasc Surg 1993;41(1):59-63.

Yamazaki F, Yokomise H, Keshavjee SH, Miyoshi S, Cardoso PF, Slutsky AS, Patterson GA. The superiority of an extracellular fluid solution over Euro-Collins' solution for pulmonary preservation. Transplantation 1990;49(4):690-4.

Yokomise H, Ueno T, Yamazaki F, Keshavjee S, Slutsky A, Patterson G. The effect and optimal time of administration of verapamil on lung preservation. Transplantation 1990;49(6):1039-43.

Ischemia / Reperfusion Injury and Oxidative Stress

Chen F, Nakamura T, Fujinaga T, Zhang J, Hamakawa H, Omasa M, Sakai H, Hanaoka N, Bando T, Wada H, Fukuse T. Protective effect of a nebulized beta2-adrenoreceptor agonist in warm ischemic-reperfused rat lungs. Ann Thorac Surg 2006;82(2):465-71.

Shoji T, Omasa M, Nakamura T, Yoshimura T, Yoshida H, Ikeyama K, Fukuse T, Wada H. Mild hypothermia ameliorates lung ischemia reperfusion injury in an ex vivo rat lung model. Eur Surg Res 2005;37(6):348-53.

Nakamura T, Vollmar B, Menger MD, Inui K, Wada H, Schafers HJ. Heme oxygenase does not contribute to control of basal vascular tone in isolated blood-perfused rat lung. J Heart Lung Transplant 2004;23(5):599-605.

Omasa M, Fukuse T, Matsuoka K, Inui K, Hyon SH, Wada H. Effect of green tea extracted polyphenol on ischemia/reperfusion injury after cold preservation of rat lung. Transplant Proc 2003;35(1):138-9.

Kawashima M, Nakamura T, Schneider S, Vollmar B, Lausberg HF, Bauer M, Menger MD, Schafers HJ. Iloprost ameliorates post-ischemic lung reperfusion injury and maintains an appropriate pulmonary ET-1 balance. J Heart Lung Transplant 2003;22(7):794-801.

Omasa M, Fukuse T, Toyokuni S, Mizutani Y, Yoshida H, Ikeyama K, Hasegawa S, Wada H. Glycine ameliorates lung reperfusion injury after cold preservation in an ex vivo rat lung model. Transplantation 2003;75(5):591-8.

Matsuoka K, Isowa N, Yoshimura T, Liu M, Wada H. Green tea polyphenol blocks h(2)o(2)-induced interleukin-8 production from human alveolar epithelial cells. Cytokine 2002;18(5):266-73.

Chen Q, Yoshimura T, Kawashima M, Hanaoka N, Fukuse T, Bando T, Wada H. A novel sialyl Lewis(x) analogue attenuates ischemia reperfusion injury in rabbit lung. Thorac Cardiovasc Surg 2002;50(5):296-300.

Tanaka T, Hosoi F, Yamaguchi-Iwai Y, Nakamura H, Masutani H, Ueda S, Nishiyama A, Takeda S, Wada H, Spyrou G, Yodoi J. Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis. Embo J 2002;21(7):1695-703.

Fukuse T, Hirata T, Ishikawa S, Shoji T, Yoshimura T, Chen Q, Matsukura T, Hanaoka N, Wada H. Optimal alveolar oxygen concentration for cold storage of the lung. Transplantation 2001;72(2):300-4.

Hirata T, Fukuse T, Hanaoka S, Matsumoto S, Chen Q, Wada H. Mitochondrial respiration as an early marker of viability in cardiac-arrested rat lungs. J Surg Res 2001;96(2):268-76.

Hirata T, Fukuse T, Ishikawa S, Hanaoka S, Chen Q, Shoji T, Wada H. "Chemical preconditioning" by 3-nitropropionate reduces ischemia-reperfusion injury in cardiac-arrested rat lungs. Transplantation 2001;71(3):352-9.

Isowa N, Liu M. Role of LPS-induced microfilament depolymerization in MIP-2 production from rat pneumocytes. Am J Physiol Lung Cell Mol Physiol 2001;280(4):L762-70.

Isowa N, Wada H. Oxidative stress and ischemia-reperfusion induced acute lug injury. New Surgery 2001;1:52-60.

Nakamura T, Vollmar B, Winning J, Ueda M, Menger MD, Schafers HJ. Heparin and the nonanticoagulant N-acetyl heparin attenuate capillary no-reflow after normothermic ischemia of the lung. Ann Thorac Surg 2001;72(4):1183-8; discussion 1188-9.

Hirata T, Fukuse T, Nakamura T, Ueda M, Kawashima M, Hitomi S, Wada H. Reperfusion lung injury after cold preservation correlates with decreased levels of intrapulmonary high-energy phosphates. Transplantation 2000;69(9):1793-801.

Isowa N, Keshavjee SH, Liu M. Role of microtubules in LPS-induced macrophage inflammatory protein-2 production from rat pneumocytes. Am J Physiol Lung Cell Mol Physiol 2000;279(6):L1075-82.

Isowa N, Yoshimura T, Kosaka S, Liu M, Hitomi S, Yodoi J, Wada H. Human thioredoxin attenuates hypoxia-reoxygenation injury of murine endothelial cells in a thiol-free condition. J Cell Physiol 2000;182(1):33-40.

Fukuse T, Hirata T, Nakamura T, Kawashima M, Hitomi S, Wada H. Influence of deflated and anaerobic conditions during cold storage on rat lungs. Am J Respir Crit Care Med 1999;160(2):621-7.

Isowa N, Xavier AM, Dziak E, Opas M, McRitchie DI, Slutsky AS, Keshavjee SH, Liu M. LPS-induced depolymerization of cytoskeleton and its role in TNF-alpha production by rat pneumocytes. Am J Physiol 1999;277(3 Pt 1):L606-15.

Okubo K, Kosaka S, Isowa N, Hirata T, Hitomi S, Yodoi J, Nakano M, Wada H. Amelioration of ischemia-reperfusion injury by human thioredoxin in rabbit lung. J Thorac Cardiovasc Surg 1997;113(1):1-9.

Aota M, Matsuda K, Isowa N, Wada H, Yodoi J, Ban T. Protection against reperfusion-induced arrhythmias by human thioredoxin. J Cardiovasc Pharmacol 1996;27(5):727-32.

Fukuse T, Hirata T, Yokomise H, Hasegawa S, Inui K, Mitsui A, Hirakawa T, Hitomi S, Yodoi J, Wada H. Attenuation of ischaemia reperfusion injury by human thioredoxin. Thorax 1995;50(4):387-91.

Ono N, Yokomise H, Muro K, Inui K, Hitomi S, Yodoi J, Wada H. Expression of adult T-cell leukemia-derived factor in bronchoalveolar lavage cells after canine lung transplantation. J Thorac Cardiovasc Surg 1995;110(1):15-21.

Wada H, Hirata T, Decampos KN, Hitomi S, Slutsky AS. Effect of the combination of human thioredoxin and L-cysteine on ischemia-reperfusion injury in isolated rat lungs. Eur Surg Res 1995;27(6):363-70.

Yagi K, Liu C, Bando T, Yokomise H, Inui K, Hitomi S, Wada H. Inhibition of reperfusion injury by human thioredoxin (adult T-cell leukemia-derived factor) in canine lung transplantation. J Thorac Cardiovasc Surg 1994;108(5):913-21.

Yokomise H, Fukuse T, Hirata T, Ohkubo K, Go T, Muro K, Yagi K, Inui K, Hitomi S, Mitsui A, et al. Effect of recombinant human adult T cell leukemia-derived factor on rat lung reperfusion injury. Respiration 1994;61(2):99-104.

Ohno N, Yokomise H, Fukuse T, Hirata T, Hitomi S, Wada H. Preparation of in-vivo rat lung model for ischemia-reperfusion injury. Thorac Cardiovasc Surg 1993;41(5):304-7.

Yamazaki F, Wada H, Aoki M, Inui K, Hitomi S. An evaluation of the tolerance of the autotransplanted canine lung against warm ischemia. Jpn J Surg 1989;19(3):326-33.

Airway Healing after Transplantation

Hasegawa S, Imamura M, Shimada Y, Kanda Y, Wada H, Hitomi S, Mori K. Prostaglandin E1 ameliorates decreased tracheal blood flow after esophagectomy and aggressive upper mediastinal lymphadenectomy for esophageal carcinoma. J Am Coll Surg 1996;183(4):371-6.

Inui K, Schaefers HJ, Aoki M, Becker V, Ongsiek B, Kemnitz J, Haverich A, Borst HG. Bronchial circulation after experimental lung transplantation. The effect of long-term administration of prednisolone. J Thorac Cardiovasc Surg 1993;105(3):474-8; discussion 478-9.

Inui K, Schaefers HJ, Aoki M, Wada H, Becker V, Ongsiek B, Haverich A. Effect of methylprednisolone and prostacyclin on bronchial perfusion in lung transplantation. Ann Thorac Surg 1993;55(2):464-9.

Inui K, Takahashi Y, Hasegawa S, Hirai T, Yokomise H, Hitomi S, Takahashi M, Wada H. Effect of preoperative irradiation on wound healing after bronchial anastomosis in mongrel dogs. J Thorac Cardiovasc Surg 1993;106(6):1059-64.

Hirata T, Yamazaki F, Fukuse T, Muro K, Yokomise H, Inui K, Takahashi Y, Hirai T, Hitomi S, Wada H. Omentopexy for revascularization of free tracheal grafts in rats. Thorac Cardiovasc Surg 1992;40(4):178-81.

Takahashi Y, Hitomi S, Hirata T, Fukuse T, Yamazaki F, Cho K, Wada H. Neovascularization effect with He-Ne laser in the rat trachea. Thorac Cardiovasc Surg 1992;40(5):288-91.

Wada H, Hirata T, Inui K, Yokomise H, Hasegawa S, Fukuse T, Muro K, Hirai T, Hitomi S. Laser Doppler velocimetry measurement of canine mucosal circulation response to bronchial artery reperfusion after lung transplantation. Thorac Cardiovasc Surg 1992;40(4):182-4.

Aoki M, Schaefers HJ, Inui K, Klipsch N, Demertzis S, Kotzerke J, Haverich A, Wada H. Bronchial circulation after experimental lung transplantation: the effect of direct revascularization of a bronchial artery. Eur J Cardiothorac Surg 1991;5(11):561-5.

Yokomise H, Cardoso PF, Kato H, Keshavjee SH, Wada H, Slutsky AS, Patterson GA. The effect of pulmonary arterial flow and positive end-expiratory pressure on retrograde bronchial mucosal blood flow. J Thorac Cardiovasc Surg 1991;101(2):201-8.

Yokomise H, Wada H, Inui K, Yamazaki F, Lee M, Aoki M, Hitomi S. Application of laser Doppler velocimetry to lung transplantation. Transplantation 1989;48(4):550-4.

Immunoreaction in Lung Transplantation

Matsukura T, Yokoi A, Egawa H, Kudo T, Kawashima M, Hirata Y, Tanaka H, Kagajo K, Wada H, Tanaka K. Significance of serial real-time PCR monitoring of EBV genome load in living donor liver transplantation. Clin Transplant 2002;16(2):107-12.

Muro K, Go T, Hirata T, Fukuse T, Yokomise H, Inui K, Yodoi J, Hitomi S, Wada H. Expression of the adult T-cell leukemia-derived factor, human thioredoxin, in the allotransplanted canine lung. Surg Today 1995;25(7):626-32.

Wada H, Muro K, Hirata T, Yodoi J, Hitomi S. Rejection and expression of thioredoxin in transplanted canine lung. Chest 1995;108(3):810-4.

Hirai T, Waddell TK, DeCampos KN, Compeau CG, Wada H, Hitomi S, Patterson GA, Slutsky AS. A short course of FK506 can induce limited donor-specific graft acceptance. Ann Thorac Surg 1994;58(2):496-501.

Fukuse T, Hirai T, Yokomise H, Hasegawa S, Hirata T, Muro K, Inui K, Hitomi S, Wada H. Combined therapy with FK-506 and cyclosporine for canine lung allotransplantation: immunosuppressive effects and blood trough levels. J Heart Lung Transplant 1993;12(6 Pt 1):941-7.

Hasegawa S, Yokomise H, Hirai T, Fukuse T, Muro K, Takahashi Y, Inui K, Aoki M, Hitomi S, Wada H. Combination use of suboptimal dose of FK 506 and cyclosporine in canine lung transplantation. J Thorac Cardiovasc Surg 1992;104(5):1340-8.

Tracheal Transplantation

Yokomise H, Inui K, Wada H, Hitomi S. The infeasibility of using ten-ring irradiated grafts for tracheal allotransplantation even with omentopexy. Surg Today 1996;26(6):427-30.

Yokomise H, Inui K, Wada H, Ueda M, Hitomi S. Long-term cryopreservation can prevent rejection of canine tracheal allografts with preservation of graft viability. J Thorac Cardiovasc Surg 1996;111(5):930-4.

Yokomise H, Inui K, Wada H, Ueda M, Hitomi S, Itoh H. Split transplantation of the trachea: a new operative procedure for extended tracheal resection. J Thorac Cardiovasc Surg 1996;112(2):314-8.

Yokomise H, Inui K, Wada H, Hasegawa S, Ohno N, Hitomi S. Reliable cryopreservation of trachea for one month in a new trehalose solution. J Thorac Cardiovasc Surg 1995;110(2):382-5.

Yokomise H, Inui K, Wada H, Goh T, Yagi K, Hitomi S, Takahashi M. High-dose irradiation prevents rejection of canine tracheal allografts. J Thorac Cardiovasc Surg 1994;107(6):1391-7.

Postoperative Management after Transplantation

Chen F, Bando T, Hanaoka N, Fukuse T, Hasegawa S, Wada H. Early onset of ganciclovir-resistant cytomegalovirus infection in a lung-transplant recipient. Jpn J Thorac Cardiovasc Surg 2005;53(10):562-4.

Hasegawa S, Mori K, Inomata Y, Murakawa M, Yamaoka Y, Tanaka K. Factors associated with postoperative respiratory complications in pediatric liver transplantation from living-related donors. Transplantation 1996;62(7):943-7.

Thoracic Oncology

Fukuse T, Ogawa E, Chen F, Sakai H, Wada H. Limited surgery and radiofrequency ablation for recurrent lung cancer. Ann Thorac Surg 2006;82(4):1506-8.

Nakagawa M, Katakura H, Adachi M, Takenaka K, Yanagihara K, Otake Y, Wada H, Tanaka F. Maspin expression and its clinical significance in non-small cell lung cancer. Ann Surg Oncol 2006 Sep 29; [Epub ahead of print]

Sonobe M, Manabe T, Wada H, Tanaka F. Lung adenocarcinoma harboring mutations in the ERBB2 kinase domain. J Mol Diagn 2006;8(3):351-6.

Takenaka K, Katakura H, Chen F, Ogawa E, Adachi M, Wada H, Tanaka F. The ratio of membrane-bound form Flt-1 mRNA to VEGF mRNA correlates with tumor angiogenesis and prognosis in non-small cell lung cancer. Cancer Lett 2006.

Tanaka F, Wada H. [Efficacy of postoperative adjuvant therapy for resected non-small cell lung cancer--an evidence-based review]. Gan To Kagaku Ryoho 2006;33(3):300-6.

Ito S, Kawano Y, Katakura H, Takenaka K, Adachi M, Sasaki M, Shimizu K, Ikenaka K, Wada H, Tanaka F. Expression of MAGE-D4, a novel MAGE family antigen, is correlated with tumor-cell proliferation of non-small cell lung cancer. Lung Cancer 2006;51(1):79-88.

Katakura H, Takenaka K, Nakagawa M, Sonobe M, Adachi M, Ito S, Wada H, Tanaka F. Maspin gene expression is a significant prognostic factor in resected non-small cell lung cancer (NSCLC). Maspin in NSCLC. Lung Cancer 2006;51(3):323-8.

Nagai S, Takenaka K, Sonobe M, Ogawa E, Wada H, Tanaka F. A novel classification of MUC1 expression is correlated with tumor differentiation and postoperative prognosis in non-small cell lung cancer. J Thorac Oncol 2006;1(1):46-51.

Tsuboi M, Kato H, Nagai K, Tsuchiya R, Wada H, Tada H, Ichinose Y, Fukuoka M, Jiang H. Gefitinib in the adjuvant setting: safety results from a phase III study in patients with completely resected non-small cell lung cancer. Anticancer Drugs 2005;16(10):1123-1128.

Sonobe M, Manabe T, Wada H, Tanaka F. Mutations in the epidermal growth
factor receptor gene are linked to smoking-independent, lung adenocarcinoma.Br J Cancer 2005;93(3):355-63.

Takenaka K, Ishikawa S, Yanagihara K, Miyahara R, Hasegawa S, Otake Y,
Morioka Y, Takahashi C, Noda M, Ito H, Wada H, Tanaka F. Prognostic
Significance of Reversion-Inducing Cysteine-Rich Protein With Kazal Motifs
Expression in Resected Pathologic Stage IIIA N2 Non-Small-Cell Lung Cancer.
Ann Surg Oncol 2005.

Takenaka K, Ogawa E, Oyanagi H, Wada H, Tanaka F. Carbonyl reductase
expression and its clinical significance in non-small-cell lung cancer.
Cancer Epidemiol Biomarkers Prev 2005;14(8):1972-5.

Tanaka F, Li M, Hanaoka N, Bando T, Fukuse T, Hasegawa S, Wada H. Surgery for pulmonary nodules in breast cancer patients. Ann Thorac Surg 2005;79(5):1711-4; discussion 1714-5.

Miyahara R, Nakagawa T, Ishikawa S, Fukushima M, Wada H, Tanaka F. UFT inhibits lung metastases in spontaneous metastasis model of lung cancer. Thorac Cardiovasc Surg 2005;53(2):118-21.

Ishikawa S, Nakagawa T, Miyahara R, Kawano Y, Takenaka K, Yanagihara K, Otake Y, Katakura H, Wada H, Tanaka F. Expression of MDA-7/IL-24 and its clinical significance in resected non-small cell lung cancer. Clin Cancer Res 2005;11(3):1198-202.

Sonobe M, Tanaka F, Wada H. Lung cancer-related genes in the blood. Ann Thorac Cardiovasc Surg 2004;10(4):213-7.

Oyanagi H, Takenaka K, Ishikawa S, Kawano Y, Adachi Y, Ueda K, Wada H, Tanaka F. Expression of LUN gene that encodes a novel RING finger protein is correlated with development and progression of non-small cell lung cancer. Lung Cancer 2004;46(1):21-8.

Nakagawa M, Tanaka F, Tsubota N, Ohta M, Takao M, Wada H. A randomized phase III trial of adjuvant chemotherapy with UFT for completely resected pathological stage I non-small-cell lung cancer: the West Japan Study Group for Lung Cancer Surgery (WJSG)--the 4th study. Ann Oncol 2005;16(1):75-80.

Matsumoto S, Kimura S, Segawa H, Kuroda J, Yuasa T, Sato K, Nogawa M, Tanaka F, Maekawa T, Wada H. Efficacy of the third-generation bisphosphonate, zoledronic acid alone and combined with anti-cancer agents against small cell lung cancer cell lines. Lung Cancer 2005;47(1):31-9.

Li M, Ito H, Wada H, Tanaka F. Pit-fall sign on computed tomography predicts pleural involvement and poor prognosis in non-small cell lung cancer. Lung Cancer 2004;46(3):349-55.

Ishikawa S, Takenaka K, Yanagihara K, Miyahara R, Kawano Y, Otake Y, Hasegawa S, Wada H, Tanaka F. Matrix metalloproteinase-2 status in stromal fibroblasts, not in tumor cells, is a significant prognostic factor in non-small-cell lung cancer. Clin Cancer Res 2004;10(19):6579-85.

Chen F, Takenaka K, Ogawa E, Yanagihara K, Otake Y, Wada H, Tanaka F. Flt-4-positive endothelial cell density and its clinical significance in non-small cell lung cancer. Clin Cancer Res 2004;10(24):8548-53.

Tanaka F, Yanagihara K, Otake Y, Miyahara R, Wada H. Angiogenesis and the efficacy of postoperative administration of UFT in pathologic stage I non-small cell lung cancer. Cancer Sci 2004;95(4):371-6.

Tanaka F, Yanagihara K, Otake Y, Kawano Y, Miyahara R, Takenaka K, Katakura H, Ishikawa S, Ito H, Wada H. Prognostic factors in resected pathologic (p-) stage IIIA-N2, non-small-cell lung cancer. Ann Surg Oncol 2004;11(6):612-8.

Tanaka F, Takenaka K, Oyanagi H, Fujinaga T, Otake Y, Yanagihara K, Ito H, Wada H. Skip mediastinal nodal metastases in non-small cell lung cancer. Eur J Cardiothorac Surg 2004;25(6):1114-20.

Takenaka K, Ishikawa S, Kawano Y, Yanagihara K, Miyahara R, Otake Y, Morioka Y, Takahashi C, Noda M, Wada H, Tanaka F. Expression of a novel matrix metalloproteinase regulator, RECK, and its clinical significance in resected non-small cell lung cancer. Eur J Cancer 2004;40(10):1617-23.

Ogawa E, Takenaka K, Yanagihara K, Kurozumi M, Manabe T, Wada H, Tanaka F. Clinical significance of VEGF-C status in tumour cells and stromal macrophages in non-small cell lung cancer patients. Br J Cancer 2004.

Nakagawa T, Otake Y, Yanagihara K, Miyahara R, Ishikawa S, Fukushima M, Wada H, Tanaka F. Expression of thymidylate synthase is correlated with proliferative activity in non-small cell lung cancer (NSCLC). Lung Cancer 2004;43(2):145-9.

Tanaka F, Oyanagi H, Takenaka K, Ishikawa S, Yanagihara K, Miyahara R, Kawano Y, Li M, Otake Y, Wada H. Glomeruloid microvascular proliferation is superior to intratumoral microvessel density as a prognostic marker in non-small cell lung cancer. Cancer Res 2003;63(20):6791-4.

Tanaka F, Otake Y, Yanagihara K, Kawano Y, Miyahara R, Li M, Ishikawa S, Wada H. Correlation between apoptotic index and angiogenesis in non-small cell lung cancer: comparison between CD105 and CD34 as a marker of angiogenesis. Lung Cancer 2003;39(3):289-96.

Shoji T, Isowa N, Hasegawa S, Li M, Morimoto K, Ueda H, Kitaichi M, Manabe T, Wada H. Solitary atypical adenomatous hyperplasia in the lung of a 17-year-old man with spontaneous pneumothorax. Respiration 2003;70(3):303-5.

Tanaka F, Takata T, Yamada T, Yanagihara K, Otake Y, Miyahara R, Nakagawa T, Kawano Y, Ishikawa S, Inui K, Wada H. Apoptotic tumor-cell death in response to cell proliferation is influenced by p53 status in resected non-small cell lung cancer. Lung Cancer 2002;36(1):27-32.

Tanaka F, Ishikawa S, Yanagihara K, Miyahara R, Kawano Y, Li M, Otake Y, Wada H. Expression of angiopoietins and its clinical significance in non-small cell lung cancer. Cancer Res 2002;62(23):7124-9.

Shoji T, Tanaka F, Yanagihara K, Inui K, Wada H. Phase II study of repeated intrapleural chemotherapy using implantable access system for management of malignant pleural effusion. Chest 2002;121(3):821-4.

Shoji T, Tanaka F, Takata T, Yanagihara K, Otake Y, Hanaoka N, Miyahara R, Nakagawa T, Kawano Y, Ishikawa S, Katakura H, Wada H. Clinical significance of p21 expression in non-small-cell lung cancer. J Clin Oncol 2002;20(18):3865-71.

Nakagawa T, Tanaka F, Takata T, Matsuoka K, Miyahara R, Otake Y, Yanagihara K, Fukushima M, Wada H. Predictive value of dihydropyrimidine dehydrogenase expression in tumor tissue, regarding the efficacy of postoperatively administered UFT (Tegafur + Uracil) in patients with p-stage I nonsmall-cell lung cancer. J Surg Oncol 2002;81(2):87-92.

Nakagawa T, Tanaka F, Otake Y, Yanagihara K, Miyahara R, Matsuoka K, Takata T, Yamada T, Fukushima M, Wada H. Prognostic value of thymidylate synthase expression in patients with p-stage I adenocarcinoma of the lung. Lung Cancer 2002;35(2):165-70.

Morimoto K, Miyahara R, Li M, Yanagihara K, Tanaka F, Togashi K, Ito H, Wada H. A pitfall of CT findings in peripheral lung adenocarcinoma. J Comput Assist Tomogr 2002;26(2):197-8.

Katakura H, Tanaka F, Oyanagi H, Miyahara R, Yanagihara K, Otake Y, Wada H. Clinical significance of nm23 expression in resected pathologic-stage I, non-small cell lung cancer. Ann Thorac Surg 2002;73(4):1060-4.

Isowa N, Hasegawa S, Bando T, Wada H. Preoperative risk factors for prolonged air leak following lobectomy or segmentectomy for primary lung cancer. Eur J Cardiothorac Surg 2002;21(5):951.

Hanaoka N, Tanaka F, Wada H. Prognostic Significance of p53 Status in Non-Small Cell Lung Cancer in Correlation with Postoperative Adjuvant Therapy. Thorac Cardiovasc Surg 2002;50(6):355-9.

Hanaoka N, Tanaka F, Otake Y, Yanagihara K, Nakagawa T, Kawano Y, Miyahara R, Li M, Wada H. Primary lung carcinoma arising from emphysematous bullae. Lung Cancer 2002;38(2):185-91.

Bando T, Yanagihara K, Ohtake Y, Miyahara R, Tanaka F, Hasegawa S, Inui K, Wada H. A new method of segmental resection for primary lung cancer: intermediate results. Eur J Cardiothorac Surg 2002;21(5):894-9; discussion 900.

Tanaka F, Yanagihara K, Otake Y, Yamada T, Shoji T, Miyahara R, Inui K, Wada H. Prognostic factors in patients with resected pathologic (p-) T1-2N1M0 non-small cell lung cancer (NSCLC). Eur J Cardiothorac Surg 2001;19(5):555-61.

Tanaka F, Otake Y, Yanagihara K, Yamada T, Miyahara R, Kawano Y, Li M, Inui K, Wada H. Apoptosis and p53 status predict the efficacy of postoperative administration of UFT in non-small cell lung cancer. Br J Cancer 2001;84(2):263-9.

Tanaka F, Otake Y, Yanagihara K, Kawano Y, Miyahara R, Li M, Yamada T, Hanaoka N, Inui K, Wada H. Evaluation of angiogenesis in non-small cell lung cancer: comparison between anti-CD34 antibody and anti-CD105 antibody. Clin Cancer Res 2001;7(11):3410-5.

Tanaka F, Otake Y, Nakagawa T, Kawano Y, Miyahara R, Li M, Yanagihara K, Inui K, Oyanagi H, Yamada T, Nakayama J, Fujimoto I, Ikenaka K, Wada H. Prognostic significance of polysialic acid expression in resected non-small cell lung cancer. Cancer Res 2001;61(4):1666-70.

Takata T, Tanaka F, Yamada T, Yanagihara K, Otake Y, Kawano Y, Nakagawa T, Miyahara R, Oyanagi H, Inui K, Wada H. Clinical significance of caspase-3 expression in pathologic-stage I, nonsmall-cell lung cancer. Int J Cancer 2001;96(Suppl):54-60.

Miyahara R, Tanaka F, Nakagawa T, Matsuoka K, Isii K, Wada H. Expression of neural cell adhesion molecules (polysialylated form of neural cell adhesion molecule and L1-cell adhesion molecule) on resected small cell lung cancer specimens: in relation to proliferation state. J Surg Oncol 2001;77(1):49-54.

Kawano Y, Sasaki M, Nakahira K, Yoshimine T, Shimizu K, Wada H, Ikenaka K. Structural characterization and chromosomal localization of the MAGE-E1 gene. Gene 2001;277(1-2):129-37.

Fukuse T, Hirata T, Tanaka F, Wada H. The prognostic significance of malignant pleural effusion at the time of thoracotomy in patients with non-small cell lung cancer. Lung Cancer 2001;34(1):75-81.

Tanaka F, Yanagihara K, Otake Y, Miyahara R, Kawano Y, Nakagawa T, Shoji T, Wada H. Surgery for non-small cell lung cancer: postoperative survival based on the revised tumor-node-metastasis classification and its time trend. Eur J Cardiothorac Surg 2000;18(2):147-55.

Tanaka F, Fukuse T, Wada H, Fukushima M. The history, mechanism and clinical use of oral 5-fluorouracil derivative chemotherapeutic agents. Curr Pharm Biotechnol 2000;1(2):137-64.

Tanaka T, Nakamura H, Nishiyama A, Hosoi F, Masutani H, Wada H, Yodoi J. Redox regulation by thioredoxin superfamily; protection against oxidative stress and aging. Free Radic Res 2000;33(6):851-5.

Tanaka F, Yanagihara K, Otake Y, Li M, Miyahara R, Wada H, Ito H. Biological features and preoperative evaluation of mediastinal nodal status in non-small cell lung cancer. Ann Thorac Surg 2000;70(6):1832-8.

Tanaka F, Otake Y, Nakagawa T, Kawano Y, Miyahara R, Li M, Yanagihara K, Nakayama J, Fujimoto I, Ikenaka K, Wada H. Expression of polysialic acid and STX, a human polysialyltransferase, is correlated with tumor progression in non-small cell lung cancer. Cancer Res 2000;60(11):3072-80.

Fukuse T, Hirata T, Naiki H, Hitomi S, Wada H. Prognostic significance of proliferative activity in pN2 non-small-cell lung carcinomas and their mediastinal lymph node metastases. Ann Surg 2000;232(1):112-8.

Fukuse T, Hirata T, Naiki H, Hitomi S, Wada H. Prognostic significance of cyclin E overexpression in resected non-small cell lung cancer. Cancer Res 2000;60(2):242-4.

Yanagihara K, Kato E, Hitomi S, Sunamoto J, Wada H. Activation of human T lymphocytes by ganglioside-containing liposomes. Glycoconj J 1999;16(1):59-65.

Wada H, Miyahara R, Tanaka F, Hitomi S. Postoperative adjuvant chemotherapy with PVM (Cisplatin + Vindesine + Mitomycin C) and UFT (Uracil + Tegafur) in resected stage I-II NSCLC (non-small cell lung cancer): a randomized clinical trial. West Japan Study Group for lung cancer surgery (WJSG). Eur J Cardiothorac Surg 1999;15(4):438-43.

Wada H. Adjuvant treatment of early stage non-small-cell lung cancer. Oncology (Huntingt) 1999;13(7 Suppl 3):102-5.

Tanaka F, Yanagihara K, Ohtake Y, Miyahara R, Kawano Y, Fukuse T, Hitomi S, Wada H. p53 status predicts the efficacy of postoperative oral administration of tegafur for completely resected non-small cell lung cancer. Jpn J Cancer Res 1999;90(4):432-8.

Tanaka F, Kawano Y, Li M, Takata T, Miyahara R, Yanagihara K, Ohtake Y, Fukuse T, Wada H. Prognostic significance of apoptotic index in completely resected non-small-cell lung cancer. J Clin Oncol 1999;17(9):2728-36.

Otake Y, Tanaka F, Yanagihara K, Hitomi S, Okabe H, Fukushima M, Wada H. Expression of thymidylate synthase in human non-small cell lung cancer. Jpn J Cancer Res 1999;90(11):1248-53.

Nakamura T, Ohno T, Hirota K, Nishiyama A, Nakamura H, Wada H, Yodoi J. Mouse glutaredoxin - cDNA cloning, high level expression in E. coli and its possible implication in redox regulation of the DNA binding activity in transcription factor PEBP2. Free Radic Res 1999;31(4):357-65.

Fukuse T, Hirata T, Naiki H, Hitomi S, Wada H. Expression of proliferating cell nuclear antigen and CD44 variant isoforms in the primary and metastatic sites of nonsmall cell lung carcinoma with intrapulmonary metastases. Cancer 1999;86(7):1174-81.

Yokomise H, Mizuno H, Ike O, Wada H, Hitomi S, Itoh H. Importance of intrapulmonary lymph nodes in the differential diagnosis of small pulmonary nodular shadows. Chest 1998;113(3):703-6.

Wada H, Nakamura T, Nakamoto K, Maeda M, Watanabe Y. Thirty-day operative mortality for thoracotomy in lung cancer. J Thorac Cardiovasc Surg 1998;115(1):70-3.

Tanaka F, Miyahara R, Ohtake Y, Yanagihara K, Fukuse T, Hitomi S, Wada H. Advantage of post-operative oral administration of UFT (tegafur and uracil) for completely resected p-stage I-IIIa non-small cell lung cancer (NSCLC). Eur J Cardiothorac Surg 1998;14(3):256-62; discussion 263-4.

Tanaka F, Miyahara R, Ohtake Y, Yanagihara K, Fukuse T, Hitomi S, Wada H. Lewis Y antigen expression and postoperative survival in non-small cell lung cancer. Ann Thorac Surg 1998;66(5):1745-50.

Hirata T, Fukuse T, Naiki H, Hitomi S, Wada H. Expression of CD44 variant exon 6 in stage I non-small cell lung carcinoma as a prognostic factor. Cancer Res 1998;58(6):1108-10.

Wada H, Tanaka F, Hitomi S. Postoperative adjuvant chemotherapy for non-small-cell lung cancer. West Japan Study Group for Lung Cancer Surgery. The Japan Lung Cancer Research Group on Postsurgical Adjuvant Chemotherapy. Oncology (Huntingt) 1997;11(9 Suppl 10):98-102.

Tanaka F, Yanagihara K, Ohtake Y, Fukuse T, Hitomi S, Wada H. Time trends and survival after surgery for p-stage IIIa, pN2 non-small cell lung cancer (NSCLC). Eur J Cardiothorac Surg 1997;12(3):372-9.

Nakano K, Ike O, Wada H, Hitomi S, Amano Y, Ogita I, Nakai N, Takada K. Oral sustained-release cisplatin preparation for rats and mice. J Pharm Pharmacol 1997;49(5):485-90.

Go T, Isowa N, Hirata T, Yodoi J, Hitomi S, Wada H. Thymic interdigitating cells express thioredoxin (TRX/ADF): an immunohistochemical study of 82 thymus and thymoma samples. Thymus 1997;24(3):157-71.

Fukuse T, Wada H, Hitomi S. Extended operation for non-small cell lung cancer invading great vessels and left atrium. Eur J Cardiothorac Surg 1997;11(4):664-9.

Fukuse T, Hirata T, Tanaka F, Yanagihara K, Hitomi S, Wada H. Prognosis of ipsilateral intrapulmonary metastases in resected nonsmall cell lung cancer. Eur J Cardiothorac Surg 1997;12(2):218-23.

Yagi K, Hirata T, Fukuse T, Yokomise H, Inui K, Ike O, Mizuno H, Aoki M, Hitomi S, Wada H. Surgical treatment for invasive thymoma, especially when the superior vena cava is invaded. Ann Thorac Surg 1996;61(2):521-4.

Wada H, Tanaka F, Yanagihara K, Ariyasu T, Fukuse T, Yokomise H, Inui K, Mizuno H, Ike O, Hitomi S. Time trends and survival after operations for primary lung cancer from 1976 through 1990. J Thorac Cardiovasc Surg 1996;112(2):349-55.

Wada H, Hitomi S, Teramatsu T. Adjuvant chemotherapy after complete resection in non-small-cell lung cancer. West Japan Study Group for Lung Cancer Surgery. J Clin Oncol 1996;14(4):1048-54.

Okubo K, Yagi K, Yokomise H, Inui K, Wada H, Hitomi S. Extensive resection with selective cerebral perfusion for a lung cancer invading the aortic arch. Eur J Cardiothorac Surg 1996;10(5):389-91.

Houjou T, Nakano K, Ike O, Wada H, Hitomi S, Shinmi Y, Danno N, Yoshikawa Y, Takada K. Oral sustained-release cisplatin capsule. J Pharm Pharmacol 1996;48(5):474-8.

Wada H, Yokomise H, Tanaka F, Hirata T, Fukuse T, Bando T, Inui K, Ike O, Mizuno H, Hitomi S. Surgical treatment of small cell carcinoma of the lung: advantage of preoperative chemotherapy. Lung Cancer 1995;13(1):45-56.

Wada H, Okubo K, Hirata T, Hitomi S. Evaluation of cases with combined bronchoplasty and pulmonary arterioplasty for the treatment of lung cancer. Lung Cancer 1995;13(2):113-20.

Wada H, Fukuse T, Hitomi S. Long-term survival of surgical cases of lung cancer. Lung Cancer 1995;13(3):269-74.

Okubo K, Wada H, Fukuse T, Yokomise H, Inui K, Ike O, Mizuno H, Aoki M, Hitomi S. Treatment of Pancoast tumors. Combined irradiation and radical resection. Thorac Cardiovasc Surg 1995;43(5):284-6.

Respiratory Physiology

keyama K, Sakai H, Omasa M, Hamakawa H, Nakamura T, Fujinaga T, Fukuse T, Wada H. Influence of inflated lung pressure on lung mechanical properties during cold storage in rats. Eur Surg Res 2006;38(1):48-53.

Ikeyama K, Sakai H, Omasa M, Nakamura T, Hamakawa H, Fujinaga T, Fukuse T, Wada H. Effects of cold preservation on the lung mechanical properties in rats. Eur Surg Res 2005;37(2):85-91.

Shoji T, Oku Y, Ishikawa S, Wada H. Thoracoscopic electrode implantation for diaphragm pacing in dogs. Respiration 2002;69(1):69-74.

Sakai H, Ingenito EP, Mora R, Abbay S, Cavalcante FS, Lutchen KR, Suki B. Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities. J Appl Physiol 2001;91(2):737-47.

Regenerative Medicine

Kono T, Kubo H, Shimazu C, Ueda Y, Takahashi M, Yanagi K, Fujita N, Tsuruo T, Wada H, Yamashita JK. Differentiation of lymphatic endothelial cells from embryonic stem cells on OP9 stromal cells. Arterioscler Thromb Vasc Biol 2006;26(9):2070-6.

Operations in Thoracic Surgery

Matsumoto S, Hirata T, Ogawa E, Fukuse T, Ueda H, Koyama T, Nakamura T, Wada H. Ultrasonographic evaluation of small nodules in the peripheral lung during video-assisted thoracic surgery (VATS). Eur J Cardiothorac Surg 2004;26(3):469-73.

Hirata T, Fukuse T, Mizuno H, Hitomi S, Wada H. Clinical application of biodegradable rib connecting pins in thoracotomy. Thorac Cardiovasc Surg 1999;47(3):183-7.

Yokomise H, Fukuse T, Ike O, Inui K, Mizuno H, Wada H, Hitoni S. Unsuccessful omentopexy in thoracic surgery. Thorac Cardiovasc Surg 1997;45(3):145-8.

Tanaka F, Wada H, Hitomi S, Itoh M. Surgery for complications of chronic obstructive lung disease. Chest Surg Clin N Am 1995;5(4):797-813.

Yokomise H, Takahashi Y, Inui K, Yagi K, Mizuno H, Aoki M, Wada H, Hitomi S. Omentoplasty for postpneumonectomy bronchopleural fistulas. Eur J Cardiothorac Surg 1994;8(3):122-4.

Bronchoscopy / Airway Management

Tanaka F, Muro K, Yamasaki S, Watanabe G, Shimada Y, Imamura M, Hitomi S, Wada H. Evaluation of tracheo-bronchial wall invasion using transbronchial ultrasonography (TBUS). Eur J Cardiothorac Surg 2000;17(5):570-4.

Yanagihara K, Mizuno H, Wada H, Hitomi S. Tracheal stenosis treated with self-expanding nitinol stent. Ann Thorac Surg 1997;63(6):1786-9; discussion 1789-90.

Hasegawa S, Hitomi S, Murakawa M, Mori K. Development of an ultrathin fiberscope with a built-in channel for bronchoscopy in infants. Chest 1996;110(6):1543-6.

Hasegawa S, Tanaka K, Egawa H, Inomata Y, Murakawa M, Terada Y, Matsui T, Arai T, Yamaoka Y, Mori K. Perioperative respiratory management with fiberoptic bronchoscopy in pediatric living-related liver transplantation. Surgery 1996;119(2):198-201.

Rare Cases

Chen F, Hasegawa S, Bando T, Kitaichi M, Hiratsuka T, Kawashima M, Hanaoka N, Yoshimura T, Tanaka F, Trulock EP, Wada H. Recurrence of bilateral diffuse bronchiectasis after bilateral lung transplantation. Respirology 2006;11(5):666-8.

Komatsu T, Fukuse T, Wada H, Sakurai T. Pulmonary sclerosing hemangioma with pulmonary metastasis. Thorac Cardiovasc Surg 2006;54(5):348-9.

Katakura H, Sato M, Tanaka F, Sakai H, Bando T, Hasegawa S, Nakashima Y, Wada H. Pulmonary sclerosing hemangioma with metastasis to the mediastinal lymph node. Ann Thorac Surg 2005;80(6):2351-3.

Ito S, Isowa N, Li M, Hasegawa S, Wada H. Parasternal lymph node metastasis of malignant peritoneal mesothelioma: report of a case. Surg Today 2005;35(9):782-4.

Chen F, Fukuse T, Hasegawa S, Bando T, Hanaoka N, Kawashima M, Sakai H, Komeda M, Wada H. Living-donor lobar lung transplantation for pulmonary and abdominopelvic lymphangioleiomyomatosis. Thorac Cardiovasc Surg 2005;53(2):125-7.

Omasa M, Hasegawa S, Bando T, Okano Y, Otani H, Nakashima Y, Wada H. A case of congenital pulmonary vein stenosis in an adult. Respiration 2004;71(1):92-4.